Remdesivir – The potential Treatment for COVID19
The research to bring the potential cure for the covid19 disease is undergoing across the world. Different research teams and pharmaceutical companies and working to bring the cure at the earliest possible. Even many organizations are funding the research to stop the present pandemic situation and come out to normalcy very soon.
Different countries have tried different already existing drugs for the treatment and only very few are found to be little effective in helping to help recover covid19 patients. It is important to note that as of today(June 2nd 2020) No potential drug or cure is available for covid19. Only a few drugs are being claimed to help in recovering the patients soon.
On Monday, June 1st 2020, Indian top drug regulatory authority has cleared for the use of the most famous Antiviral drug for the treatment of severe covid19 patients. The drug is known as Remdesivir. The regulatory cleared for the use of the drug only against laboratory-confirmed covid19 patients or suspected patients and can administer only to a maximum of 5 days. This is to prevent the effect of the drug on the patients. It is believed that using the drug will help in recovering from covid19 fastly but it is not a complete drug for the treatment of covid19. Hence guidelines have been given by the regulatory authority for the use of this drug.
What is REMDESIVIR drug?
REMDESIVIR is an antiviral drug developed by Pharmaceutical company Gilead Sciences. The drug was developed during the research to find a drug for Hepatitis. This drug though was not successful in treatment for Hepatitis but was helpful in the treatment of Ebola virus. Earlier studies indicate that the drug has antiviral effects against SARS and MERS coronavirus, but was ineffective in the treatment of both of these diseases.
The United States Food and Drug Administration (US FDA) describes Remdesivir as a nucleoside ribonucleic acid (RNA) polymerase inhibitor.
REMDESIVIR for covid19 treatment
Ever since the potentiality of covid19 disease is visible across the globe, scientists across are working day and night to find the potential cure or drug for the treatment. Different combinations of different drugs are being tested in different countries to find effectiveness in the treatment of disease. But only a few are found to be effective in helping the patients to recover. Out of these few REMDESIVIR is found to be most effective in shortening the time required by the patients to recover. Thus research has been done on this drug in trail to find the effectiveness of these antiviral drugs for the treatment of coronavirus.
In the trials conducted by the research organizations, the data clearly indicate that Remdisivir has clear cut positive effect in diminishing the time required for the recovery of the patients.
The drug was first tested on monkeys during the trails and was found to be most promising. When testing on animals the drug didn’t show any negative effect on the breathing of animals and also there is not any seen damage to the lungs of the animals. This is the positive step that made the scientists understand the positive effect of the drug.
The drug was latest to trail stage where almost 1000 patients were part of the trail and it was found that patients showed a drop in recovery time from 15 days to 11 days. But it is too soon to declare the drug as potential without further observation.
Though the results are somewhat promising considering there is almost 30% drop in the recovery time, which may help severely affected patients and can have the potential to reduce the mortality rate by almost 30%. This is somewhat convincing considering the situation that till now no other drug combination has been proven to be effective in the fight against the treatment of covid19.
International Situation on drug
My Trump has been from the past at multiple times said that the famous Hydrochloquine, the anti-malarial drug to be a great drug and the potential drug for the treatment of covid19 patients. But different researchers have claimed that this drug will have some adverse effects on some patients and cannot be administered to all the patients. Even WHO said that this drug cannot be proved to be effective against covid19 disease. Trump also said on Remdesivir that this drug can help in the fight against covid19 and the regulators should speed the process of approval ao that the drug can reach the patients soon.
Japan also announced that this drug can be used as a potential one to help in reducing the time of recovery of patients. Japan became the second country to authorise the drug for the treatment of covid19.
India also on Monday 2nd June has authorized to use the drug for the treatment against covid19. But the Indian government has authorized to use the drug to a maximum of 5 days to a single patient. This is to based on the data that the recovery rate remains the same even if it is administered for 10 days of 5 days. US company has said that the drug can be used for a maximum of 10 days. but Indian regulatory authority with cautious has only approved to use for a maximum of 5 days.
Gilead licenses Remdesivir for Covid-19 to generic companies for sale in 127 countries
The US company that is behind the famous Remdesivir drug has signed hand full of agreements to scale up the production of the drug in low income and high-income countries. The company has said that it has signed a non-exclusive voluntary agreement with five generic companies based in India and Pakistan – Cipla, Ferozsons Labs, Hetero Labs, Jubilant Lifesciences and Mylan to manufacture and distribute the drug to 127 countries.
It is also to be noted that the license is royalty-free until the WHO announces an end to the present pandemic situation across the globe. It also said that companies can increase the manufacturing and sell their own prices. The technology is transferred to the generic companies and they can scale up the production to reach the maximum countries.
This is with respect to the famous drug for the treatment of covid19 disease. But is not yet considered as a complete treatment solution for covid19. It is just a relief to the present situation to speed up the recovery rate. Hopefully, a complete drug to treat covid19 will come in future. That is with regarding Remdesivir. We will bring another insightful article to you soon
Thanks and stay safe stay healthy.